F3520
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 | Immunofluorescence Equine exuberant granulation (proud flesh) tissue stained using Anti-von Willebrand Factor (Cat. No. F3520) at a 1:100 dilution and Anti-Rabbit IgG-FITC (Cat. No. F0382) (green) and DAPI (blue). From Lynn Burgess, Natural Sciences Department, Dickinson State University, Dickinson, ND. |
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F3520
Sigma
Anti-von Willebrand Factor antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| Synonym: | Anti-Factor VIII-Related Antigen |
| MDL number: | MFCD00162556 |
Description
| Immunogen | von Willebrand Factor (Factor VIII-related antigen) from human plasma. |
| Specificity | The antibody specifically reacts with the cytoplasm of human endothelial cells from normal and neoplastic blood and from lymphatic vessels. It also reacts with human endocardium, platelets and megakaryocytes. It may be used for immunohistological studies of the vascular structures in frozen tissue preparations and enzymatically pre-digested, formalin, methacarn, Bouin′s or ethanol-fixed and paraffin-embedded tissue sections. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| species reactivity | human |
| application(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:800 using human tissue sections |
| immunohistochemistry (frozen sections): suitable | |
| Gene Information | human ... VWF(7450) |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
References
| reference | Kwaasi, A., et al., Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: a potential occult barrier to xenotransplantation. Am. J. Pathol. 151, 111-120, (1997) Abstract |
| Hinek, A., et al., Connection between Elastin Haploinsufficiency and Increased Cell Proliferation in Patients with Supravalvular Aortic Stenosis and Williams-Beuren Syndrome Am. J. Hum. Genet. 71, 30-44, (2002) Abstract |
